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Estrace (generic name: Estradiol) belongs to the class of medications known as estrogen replacement therapy.

Estrace is used:

To manage various symptoms of menopause including abnormal uterine bleeding; hot flashes; vaginal itching, burning, or dryness; vulval or vaginal atrophy
To prevent osteoporosis (brittle bones)
For estrogen replacement therapy after failure of the ovaries
In the treatment of breast cancer and advanced prostate cancer

Estrace is a female estrogen hormone. It works by replacing natural estrogens in a woman who can no longer produce enough estrogen. It works for advanced prostate cancer by antagonizing male hormones.

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